If a guardian in the proband is known to have the pathogenic variant determined while in the proband, the danger to the sibs of inheriting the pathogenic variant is fifty%. Because of diminished penetrance, sibs who inherit the pathogenic variant may or may not produce aHUS (see Penetrance). The ACR https://connernhzrf.estate-blog.com/32062753/the-smart-trick-of-air-handling-units-ahus-that-no-one-is-discussing